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Updated: Aug 8, 2026

Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes
Published on: February 13, 2019
Avermectins and flea control: structure-activity relationships and the selection of selamectin for development as an
B J Banks1, B F Bishop, N A Evans
1Pfizer Central Research, Sandwich, Kent, UK. bernard_banks@sandwich.pfizer.com
Abstract:
Evaluation of a wide range of avermectin derivatives for flea activity in an in vitro feeding screen using the cat flea, Ctenocephalides felis, revealed a narrow structure-activity relationship (SAR) with activity surprisingly associated with monosaccharides and especially their C-5-oximes. We discovered commercially exploitable flea activity in a single compound, selamectin 33, which also possessed the necessary antiparasitic spectrum and margin of safety for development as a broad-spectrum companion animal endectocide.
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