Related Experiment Videos
Synthesis and antimicrobial activity of squalamine analogue
1Department of Industrial Chemistry, Kyungpook National University, Taegu, South Korea. kimhs@knu.ac.kr
Bioorganic & Medicinal Chemistry
|September 26, 2000
Abstract:
Synthesis and antimicrobial activity of squalamine analogue 2 are reported. The synthesis of 2 was accomplished from bisnoralcohol 3. The spermidine moiety was introduced via reductive amination of an appropriately functionalized 3beta-aminosterol with spermidinyl aldehyde 17 utilizing sodium triacetoxyborohydride as the reducing agent. Compound 2 shows weaker antimicrobial activity than squalamine.