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Prognostic value of mitotic metaphase rate in oesophageal cancer
M Yasunaga1, Y Tabira, S Imaoka
1First Department of Surgery, School of Medicine, Kumamoto University, Japan.
Objective:
To assess the prognostic value of the mitotic metaphase rate in patients with oesophageal cancer.
Design:
Retrospective study.
Setting:
University hospital, Japan.
Subjects:
41 patients with oesophageal cancer.
Interventions:
We calculated the ratio of mitotic metaphase to anaphase cells among tumour cells in sections stained with haematoxylin and eosin, a ratio that shows the status of mitotic metaphase-anaphase transition. The DNA ploidy pattern was examined by flow cytometry.
Main Outcome Measure:
Correlation between survival and mitotic metaphase rate.
Results:
A high mitotic metaphase rate was correlated with vascular invasion and is expected to be a useful prognostic factor. DNA diploidy combined with a low rate was an independent favorable prognostic factor.
Conclusion:
Mitotic metaphase rate is a useful index of malignant potential, independent of DNA ploidy. It can distinguish high malignant potential from low in a diploid tumour, which has a poor prognosis that is equal to that of the aneuploidy tumour.
