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Acute megakaryoblastic leukemia in Down syndrome: orbital infiltration
1Ophthalmology Rocky Mountain Lions Eye Institute, Denver, Colorado, 80262, USA.
Purpose:
To describe an uncommon ocular presentation of acute megakaryoblastic leukemia in a child with Down syndrome.
Method:
Case report. Initial manifestation of disease was bilateral proptosis with secondary exposure keratitis caused by leukemic infiltration of the orbits.
Results:
Bone marrow biopsy and immunophenotyping established the diagnosis of acute megakaryoblastic leukemia (FAB-M7). The leukemia was treated successfully with chemotherapy, with resolution of proptosis. The patient remained in remission more than 1 year after cessation of treatment.
Conclusions:
Bilateral proptosis can be a presenting sign of acute megakaryoblastic leukemia, a malignancy associated with Down syndrome.