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Cloning and characterization of a novel RNA-binding protein SRL300 with RS domains
1Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, Central Ward, Sapporo, Japan. ysawada@sapmed.ac.jp
Biochimica Et Biophysica Acta
|September 27, 2000
Abstract:
AT-rich element binding factor 1 (ATBF1) mRNA encodes a transcription factor implicated in neuronal differentiation. A cDNA for the protein that can bind the 5'-noncoding sequence of the ATBF1 mRNA was cloned. The deduced protein, termed SRL300, contains a unique RNA-binding region, two large RS domains and many phosphorylation sites. SRL300 protein was detected in both human and rat cells.