Related Experiment Video
Updated: Aug 15, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
[Drug therapy for nocturnal gastric acid breakthrough]
1Shimane Medical University, Department of Medicine II.
Abstract:
Nocturnal gastric acid breakthrough(NAB) is defined as nighttime periods of over 1 hour duration, with a gastric pH < 4.0, during administration of a proton pump inhibitor(PPI). Although the causative mechanism of NAB is unclear, this phenomenon is a serious problem for patients with high grade reflux esophagitis. NAB is more frequently observed in patients with reflux esophageals, since this phenomenon is mainly observed in cases without H. pylori infection. Bedtime administration of H2 receptor antagonist rather than additional administration of PPI on the standard dose of PPI is effective for the control of NAB.
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