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Chronic myelomonocytic leukaemia in a child with constitutional partial trisomy 8 mosaicism
A F Brady1, C S Waters, M J Pocha
1Kennedy-Galton Centre, North West London Hospitals NHS Trust, Harrow, Middlesex, UK. a.brady@ic.ac.uk
Clinical Genetics
|September 27, 2000
Abstract:
We present a 3-year-old boy with constitutional partial trisomy 8 mosaicism (karyotype 47,XY, + del(8)(p12)/46,XY) who developed chronic myelomonocytic leukaemia and we review the few reported cases of constitutional trisomy 8 mosaicism (CT8M) associated with malignancy. This case highlights the association between CT8M and the development of malignancies, haematological malignancies in particular.