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Related Experiment Videos

Invasion and distribution of methanol.

M Graw1, H T Haffner, L Althaus

  • 1Institute of Forensic Medicine, University of Tübingen, Germany. matthias.graw@gmx.de

Archives of Toxicology
|September 27, 2000
PubMed
Summary

Ethanol blocks methanol oxidation. Studies show methanol distribution volume is similar to ethanol, with rapid absorption and distribution half-lives for both oral and parenteral administration in humans.

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Area of Science:

  • Toxicology
  • Pharmacokinetics

Background:

  • Methanol is a toxic alcohol requiring metabolic processing.
  • Ethanol is known to inhibit methanol oxidation.
  • Understanding methanol's pharmacokinetic profile is crucial for managing toxicity.

Purpose of the Study:

  • To investigate the pharmacokinetic parameters of methanol in humans.
  • To compare the distribution and absorption of methanol with ethanol.
  • To determine methanol's distribution volume and half-life after oral and parenteral administration.

Main Methods:

  • Five human subjects received methanol (approx. 10 mg/kg) orally and parenterally after ethanol administration to block oxidation.
  • Blood methanol concentrations were measured to determine C0 levels.
  • Distribution volume and half-life (distribution and invasion) were calculated.

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Main Results:

  • Methanol C0 concentrations ranged from 11.1-15.9 mg/kg.
  • The distribution volume of methanol was approximately 0.77 L/kg, comparable to ethanol (0.78 L/kg).
  • Parenteral administration showed a distribution half-life of ~8 min; oral administration had an invasion half-life of ~5 min.

Conclusions:

  • Methanol exhibits a distribution volume similar to ethanol in humans.
  • Methanol is rapidly absorbed and distributed following both oral and parenteral routes.
  • Ethanol effectively inhibits methanol metabolism, allowing for pharmacokinetic assessment.