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p53 and Bax implication in NMDA induced-apoptosis in mouse hippocampus
M Djebaïli1, G Rondouin, V Baille
1CNRS UPR 9023, CCIPE, CNRS Laboratoire de Médecine Expérimentale-Institut de Biologie, Montpellier, France.
Neuroreport
|September 28, 2000
Abstract:
Seven days after in vivo intrahippocampal administration of NMDA, 3'-OH DNA fragmentations and Bax protein expression were detected in hippocampal neurons of p53+/+ but not p53-/- transgenic mice. Interestingly, neurons showing pycnosis, an early apoptotic phenomena, were present in all genotypes. These results confirm that apoptotic 3'OH DNA fragmentations and Bax protein induction during NMDA-induced apoptosis in adult hippocampal neurons are p53 dependent.