Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Knowledge about transplantation tolerance gained in primates.

S J Knechtle1

  • 1Department of Surgery, University of Wisconsin Hospital, Madison 53792-7375, USA. stuart@tx.surgery.wisc.edu

Current Opinion in Immunology
|September 28, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same author

Expanding the Donor Pool With Normothermic Ex Vivo Liver Perfusion: The Future Is Now.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

Regulating T Cell Behavior.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

One Size Does Not Fit All--Regional Variation in the Impact of the Share 35 Liver Allocation Policy.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Surgical technique in transplantation: how much does it matter?

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

Preclinical research in organ transplantation tolerance uses nonhuman primates to test strategies like hematopoietic chimerism and lymphocyte depletion. These approaches advance tolerance mechanisms and enable clinical trials for xenotransplantation.

Area of Science:

  • Immunology and Transplant Medicine
  • Preclinical Research Models

Background:

  • Transplantation tolerance research is crucial for long-term organ graft survival.
  • Nonhuman primate models are essential for preclinical testing of tolerance strategies.

Purpose of the Study:

  • To evaluate key strategies for achieving transplantation tolerance in a preclinical setting.
  • To advance the understanding of tolerance mechanisms and facilitate clinical translation.

Main Methods:

  • Utilizing a nonhuman-primate organ transplant model.
  • Investigating three principal approaches: hematopoietic chimerism, lymphocyte depletion, and costimulation blockade.

Main Results:

  • Significant new information on the mechanisms underlying transplantation tolerance has been generated.

Related Experiment Videos

  • The evaluated strategies have paved the way for initiating pilot clinical trials.

    • Conclusions:

    • Successful preclinical testing in nonhuman primates is vital for advancing transplantation tolerance.
    • These strategies are fundamental for the future clinical application of xenotransplantation.