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Effects of sleep loss on waking actigraphy
1Henry Ford Hospital, Sleep Disorders and Research Center and Department of Psychiatry and Behavioral Neuroscience, Wayne State University, School of Medicine, Detroit MI 48202, USA. TARoehrs@aol.com
Study Objectives:
To assess the effect of sleep loss and the effect of a sedating drug on waking actigraphy
Design:
N/A SETTING: N/A PARTICIPANTS: Seventeen healthy volunteers, aged 19-35 yrs
Interventions:
Four night-day treatments presented in a Latin Square Design: placebo-8 hr time-in-bed (TIB), placebo-4 hr TIB, placebo-0 hr TIB, and diphenhydramine 50 mg-8 hr TIB.
Measurements And Results:
After the appropriate TIB, medication was administered at 09:00 hr, the Multiple Sleep Latency Test at 09:30, 11:30, 13:30, 15:30, and 17:30 hr, and a 45 min performance battery at 10:30, 14:30, and 16:30 hr. Each day the volunteers wore actigraphs from 0700-1800 hrs. Decreasing TIB was associated with decreased daily mean sleep latency on the MSLT with 4 and 0 hrs differing from 8 hrs and each other. Daytime activity also was reduced by the reduced prior TIB. Increased inactivity relative to the 8 hr TIB developed between the 4 hr and 0 hr TIBs, with 4 hrs differing from 0 hrs, but not 8 hrs. Diphenhydramine 50 mg reduced mean daily sleep latency and increased percent inactive time relative to placebo. On the MSLT diphenhydramine was intermediate to 4 hr and 0 hr TIB and on actigraphy it was similar to 0 hr TIB.
Conclusions:
The difference in the effect of diphenhydramine on these actigraphy and MSLT may reflect the different sensitivities of the measures.