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Updated: Aug 19, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
Published on: April 26, 2024
Thyroid hormone levels and recurrence of major depression
1Mood Disorders Program and Department of Psychiatry, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. joffe@fhs.csu.mcmaster.ca
Objective:
The relationship between basal thyroid hormone levels and acute antidepressant response has been studied, but any relationship between basal thyroid hormone levels and long-term course of depressive illness has not been evaluated.
Method:
The authors used a Cox regression survival analysis to evaluate the relationship between life course of depressive illness and basal levels of thyroid hormones (triiodothyronine [T(3)], thyroxine [T(4)], and thyrotropin) in 75 outpatients with unipolar major depressive disorder.
Results:
Time to recurrence of major depression was inversely related to T(3) levels but not to T(4) levels.
Conclusions:
These data may be of clinical interest in view of the fact that T(3) is used to augment antidepressant response.
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