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The thin red line: angiogenesis in normal and malignant hematopoiesis
F Bertolini1, P Mancuso, A Gobbi
1Division of Hematology-Oncology, IRCCS European Institute of Oncology, Milan, Italy. francesco.bertolini@ieo.it
Experimental Hematology
|September 29, 2000
Abstract:
This review describes the current knowledge about cell subsets involved in vasculogenesis (i.e., differentiation of endothelial cells from mesodermal precursors) and angiogenesis (i.e., blood vessel generation from pre-existing vessels), together with recent findings about angiogenesis and antiangiogenic therapies in hematopoietic malignancies such as leukemia, lymphoma, myeloma, and myelodysplastic syndromes.