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Updated: Aug 30, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
Published on: November 13, 2016
Provocation of non-convulsive status epilepticus by tiagabine in three adolescent patients
T Balslev1, P Uldall, J Buchholt
1Division of Paediatric Neurology, Department of Paediatrics, Skejby, Arhus University Hospital, Arhus N, Denmark. skejtba@aau.dk
Abstract:
Three girls, two aged 12 years and one aged 17 years with refractory localization-related epilepsy were treated on an add-on basis with tiagabine. At dosages 22.5-30 mg/day (0.45-0.57 mg/kg/day) longstanding non-convulsive status epilepticus was noted in all three patients. The events of non-convulsive status epilepticus subsided following reduction in tiagabine dosages. In two cases, tiagabine was withdrawn, whereas it was continued at a lower dosage in one case. This is the first report of non-convulsive status epilepticus provoked by tiagabine in adolescent patients.
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