[Prevention of pregnancy in bitches with the progesterone antagonist anglepristone (alizone)]

A study was carried out between April 1997 and October 1998 to determine the effect of the progesterone antagonist, Aglépristone (Alizine), for the prevention of pregnancy. 93 bitches were treated, because of mismating, with Aglépristone. The owners were then contacted 2 weeks and 6 to 12 months after treatment to gather any information on effects noted over this period. The major questions were, was pregnancy prevented and if so what side effects were observed, if any, and whether any metropathies were diagnosed. Also noted was the beginning of the next heat and, if the bitch was mated, the fertility rate. Pregnancy was seen in only one bitch. In 51 bitches minor side effects, either singularly or in combination, such as a transient itch, vaginal discharge, reduced appetite, tiredness or attachment were observed. The fertility was not influenced by the treatment and the incidence of metropathies was unchanged.