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Molecular interaction between reversible MAO-A inhibitors and the enzyme. Application to aryloxazolidinone, a
1Facultés Universitaires Notre-Dame de la Paix, Chimie Moléculaire Structurale, Namur, Belgium. ooms@scf.fundp.ac.be
Neurobiology (Budapest, Hungary)
|September 29, 2000
Abstract:
Among the various chemical classes of monoamine oxidase A inhibitors, phenyloxazolidinone represent one of the major series. The purpose of this paper is to review the experimental (X-ray diffraction, NMR, electronic absorption spectroscopy, lipophilicity studies) and theoretical (quantum chemistry, molecular mechanics, molecular dynamics) studies which have led to the description of the mode of interaction between phenyloxazolidinone inhibitors and the MAO-A enzyme.