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Possible different fates for the hydrogen peroxide produced by rat white adipocyte amine oxidases
L Raimondi1, G Banchelli, L Sgromo
1Dept. of Pharmacology, University of Florence, Italy.
Neurobiology (Budapest, Hungary)
|September 29, 2000
Abstract:
Monoamine oxidase (MAO) and benzylamine oxidases (Bz-SSAO) of rat white adipocytes, deaminating benzylamine and tyramine produce hydrogen peroxide at different cellular levels. The peroxide produced by their activity has a very short half-life in adipocyte suspension. The addition of a catalase inhibitor allows for the recovery of the intact peroxide within the first 10-min of its production. Thus, benzylamine and tyramine-dependent peroxide recovery is different, suggesting that the fate of the peroxide produced by the two amine oxidases might be different depending on the cellular site of its production.