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Solid-phase synthesis of 1,2,3, 4-tetrahydro-beta-carboline-containing peptidomimetics
1Sphinx Pharmaceuticals, A Division of Eli Lilly and Company, Cambridge, Massachusetts 02139, USA.
Organic Letters
|September 29, 2000
Abstract:
A solid-phase method for the synthesis of 1,2,3, 4-tetrahydro-beta-carboline-containing peptidomimetics has been developed. The key step in the strategy is the Pictet-Spengler condensation of a resin-bound tryptophan-containing fragment with an Fmoc-amino aldehyde.