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Updated: Aug 7, 2026

Synthesis of a Water-soluble Metal–Organic Complex Array
Published on: October 8, 2016
Rhodium-catalyzed formylation of organomercurials: application to efficient polyol synthesis
1Department of Chemistry, Columbia University, New York, New York 10027, USA.
Abstract:
The rhodium-catalyzed formylation of organomercurials-a new transformation of organomercurials-is reported. The addition of 0.50 equiv of 1,4-diazabicyclo[2.2.2]octane (DABCO) was found to promote the reaction, and it is postulated that the DABCO acts as a ligand for mercury. Several examples are presented to document the scope of the reaction. This reaction was developed in the context of a larger program focused on the development of efficient strategies for the synthesis of polyol-derived natural products, and an efficient (8 steps) synthesis of Tolypothrix pentaether that employs this methodology is reported.
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