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[Survival in prostatic cancer, treated conservatively]
A Mesa García1, F J Pérez García
1Consejería de Salud y Servicios Sanitarios de Asturias, Avilés.
Actas Urologicas Espanolas
|September 30, 2000
Summary
Prostate cancer survival rates were low in this retrospective study, with only 17% alive at 5 years. Survival was significantly higher for localized tumors compared to invasive ones, but not influenced by patient age at diagnosis.
Area of Science:
- Urology
- Oncology
- Epidemiology
Background:
- Prostate cancer diagnosis and treatment have evolved significantly since the study period (1987-1988).
- Early detection methods like PSA testing were not as prevalent, potentially leading to diagnosis at advanced stages.
Purpose of the Study:
- To analyze prostate cancer survival rates in patients treated conservatively.
- To compare survival based on tumor stage (localized vs. invasive) and patient age at diagnosis (<70 vs. >70 years).
Main Methods:
- Retrospective analysis of 80 prostate cancer patients diagnosed between 1987-1988.
- 10-year follow-up using Kaplan-Meier curves and Cox regression.
- Stratification by tumor stage and age at diagnosis.
Main Results:
- Overall 5-year survival rate was 17%; only 1 patient survived 10 years.
- No significant difference in survival based on patient age at diagnosis.
- Significantly higher survival for localized tumors (p=0.025, RR=2.3) versus invasive tumors.
Conclusions:
- The study highlights low survival rates, likely due to advanced stage at diagnosis and older patient population.
- Current diagnostic tools (PSA) enable earlier detection in younger patients, increasing radical prostatectomy rates.
- Further research is needed to assess the impact of increased radical prostatectomies on prostate cancer mortality.