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Related Experiment Videos

Negative seizures.

K J Meador1, E Moser

  • 1Department of Neurology, Medical College of Georgia, Augusta 30912, USA. kmeador@neuro.mcg.edu

Journal of the International Neuropsychological Society : JINS
|September 30, 2000
PubMed
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Rare seizure manifestations, including neglect and depression, can be misdiagnosed. Recognizing these negative ictal phenomena is crucial for accurate epilepsy diagnosis, even without typical seizure symptoms.

Area of Science:

  • Neurology
  • Epileptology
  • Clinical Neuroscience

Background:

  • Seizures can present with diverse clinical phenomena, including less common negative manifestations.
  • Misdiagnosis of seizure disorders can arise from atypical or negative ictal symptoms.

Observation:

  • This study details a patient series exhibiting unusual ictal negative phenomena.
  • Observed phenomena included neglect syndrome, catastrophic depression, apraxia, aphasia, amnesia, homonomous hemianopsia, and hemiparesis.
  • One patient experienced recurrent episodes with periodic lateralized epileptiform discharges (PLEDs) without discernible parenchymal lesions.

Findings:

  • Ictal negative phenomena, though rare, are significant indicators of seizure activity.
  • These negative symptoms can mimic other neurological or psychiatric conditions, complicating diagnosis.

Related Experiment Videos

  • The presence of PLEDs without lesions highlights the potential for subtle electroencephalographic (EEG) findings in seizure disorders.

    • Implications:

    • Clinicians must consider seizures in the differential diagnosis of unexplained neurological deficits.
    • Awareness of negative ictal phenomena can improve diagnostic accuracy and timely treatment for epilepsy.
    • Further research into the mechanisms and recognition of these rare seizure presentations is warranted.