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Probing biopolymers with the atomic force microscope: a review
H G Hansma1, L I Pietrasanta, I D Auerbach
1Department of Physics, University of California, Santa Barbara 93106, USA.
Journal of Biomaterials Science. Polymer Edition
|September 30, 2000
Abstract:
This short review presents an overview of atomic force microscopy (AFM) of biopolymers and specific examples of some of the biopolymers that have been analyzed by AFM. These specific examples include extracellular polymeric substances on the surfaces of bacterial biofilms, condensed DNA, DNA constructs, and DNA-protein interactions. In addition, two examples are presented for AFM analyses of proteins: laminin flexing its arms in solution and neurofilaments entropically brushing away the space around themselves.