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Effects of milrinone on platelet aggregation in swine with pulmonary hypertension
H Tanaka1, K Tajimi, Y Miyajima
1Trauma and Critical Care Center and Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Purpose:
The purpose of this study was to investigate whether the effect of milrinone on platelet aggregation was related to the selectivity of vasodilation vasculature in a swine model with PH.
Materials And Methods:
To induce pulmonary hypertension, we injected two sets of acid-washed glass beads in 15 swine, which were divided into two groups (those receiving milrinone or not) and compared with each other.
Results:
The induction of pulmonary hypertension decreased the platelet count and increased the plasma levels of thromboxane B2 and 6-keto-prostaglandin F1alpha.
Conclusion:
A locally high concentration of prostaglandin I2, at least in part, may produce selectivity of vasodilation in the pulmonary vasculature.