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Related Experiment Videos

Bipolar II disorder and comorbidity.

E Vieta1, F Colom, A Martínez-Arán

  • 1Department of Psychiatry, Hospital Clinic, University of Barcelona, Spain.

Comprehensive Psychiatry
|September 30, 2000
PubMed
Summary

Bipolar II disorder diagnosis remains valid despite high comorbidity rates. Comorbid patients with bipolar II disorder show similar clinical features, except for significantly higher rates of suicidal ideation and attempts.

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Area of Science:

  • Psychiatry
  • Clinical Psychology

Background:

  • The diagnostic validity of bipolar II disorder is debated due to frequent comorbidity with other mental health conditions.
  • Non-affective disorders like substance abuse, personality disorders, and anxiety disorders often co-occur with bipolar II disorder.

Purpose of the Study:

  • To investigate the impact of comorbidity on the diagnosis of bipolar II disorder.
  • To compare clinical and course variables between bipolar II patients with and without comorbid diagnoses.

Main Methods:

  • Assessed 40 patients diagnosed with bipolar II disorder using the Research Diagnostic Criteria (RDC).
  • Utilized the Schedule for Affective Disorders and Schizophrenia, Lifetime Version (SADS-L) and Structured Clinical Interview for DSM-III-R axis I (SCID-II) for assessments.
  • Compared patients with any psychiatric or personality disorder comorbidity against those without.

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Main Results:

  • Approximately 50% of bipolar II patients had lifetime comorbidity, primarily personality disorders (33%), substance abuse (21%), and anxiety disorders (8%).
  • Patients with comorbidity exhibited significantly higher rates of suicidal ideation (74% vs. 24%) and suicide attempts (45% vs. 5%).
  • Most other clinical and course variables were similar between comorbid and non-comorbid groups.

Conclusions:

  • High rates of comorbidity exist in bipolar II disorder, particularly with personality, substance abuse, and anxiety disorders.
  • Comorbidity in bipolar II disorder is strongly associated with increased suicidal behavior.
  • Despite high comorbidity, the diagnostic validity of bipolar II disorder is supported as most variables remain similar, except for suicidal behavior.