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Hydrogen bonding in salicylsalicylic acid (salsalate) crystals
P J Cox1, G I Gilmour, S M MacManus
1School of Pharmacy, The Robert Gorrdon University, Aberdee, UK. p.j.cox@rgu.ac.uk
International Journal of Pharmaceutics
|September 30, 2000
Abstract:
An X-ray crystallographic study of the drug salsalicylic acid (salsalate) has been performed. Crystal formation of the drug is influenced by both inter- and intra-molecular hydrogen bonding. In addition an OH group in salsalate can occupy alternate ortho positions resulting in two hydrogen bonding motifs within a single crystal.