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Construction of two-stranded alpha-helix peptides based on influenza virus M1 protein selectively bound to RNA
H Kuribayashi1, T Takahashi, K Nagata
1Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan.
Bioorganic & Medicinal Chemistry Letters
|September 30, 2000
Abstract:
Various 2alpha-helix peptides were designed and synthesized based on the RNA-binding region of matrix protein M1 in influenza virus. The binding properties of the peptides to model ssRNA, ssDNA, dsDNA, and virus RNA were examined by the fluorescence studies of a dansyl group incorporated into the peptides. The peptide containing the hydrophilic residues of M1 RNA-binding region bound RNAs selectively.