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Related Experiment Videos

Plasmapheresis-related hypotension.

J H Yeh1, H C Chiu

  • 1Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.

Artificial Organs
|September 30, 2000
PubMed
Summary
This summary is machine-generated.

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Hypotension is a rare complication during double filtration plasmapheresis (DFP), affecting 1.5% of sessions. Patients with autonomic nerve system issues or low baseline blood pressure are at higher risk, especially during the first session.

Area of Science:

  • Nephrology
  • Neurology
  • Critical Care Medicine

Background:

  • Hypotension is an uncommon complication of extracorporeal circulation procedures.
  • Plasmapheresis, a blood purification technique, involves extracorporeal circulation.

Purpose of the Study:

  • To investigate the incidence and characteristics of hypotension during double filtration plasmapheresis (DFP).
  • To identify risk factors and patient populations susceptible to DFP-induced hypotension.

Main Methods:

  • Retrospective analysis of 1,137 DFP sessions in 139 patients from November 1993 to March 1999.
  • Hypotension defined as systolic blood pressure < 80 mm Hg or significant BP decrease with reactions.
  • Analysis of patient demographics, underlying diseases, and DFP session parameters.

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Main Results:

  • 17 episodes (1.5%) of hypotension occurred in 15 patients.
  • Higher incidence in patients with inflammatory neuropathy (2.3%) and those with autonomic nerve system involvement or low baseline BP.
  • Symptomatic hypotension was associated with higher pre-DFP systolic BP and greater BP/pulse rate drops.

Conclusions:

  • DFP-related hypotension occurs in 1.5% of sessions, particularly in patients with autonomic instability and low blood pressure.
  • Vigilant blood pressure monitoring is crucial, especially during the initial and terminal phases of DFP treatment.
  • Prompt management with saline infusion effectively resolved most hypotensive episodes.