Related Experiment Video
Updated: Aug 11, 2026

11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Incipient osteomalacia occurring in chronic actinic dermatitis
1St John's Institue of Dermatology, London, UK. roby@rakhit.freeserve.co.uk
Clinical and Experimental Dermatology
|September 30, 2000
Summary
Strictly avoiding sunlight for chronic actinic dermatitis led to vitamin D deficiency osteomalacia in a UK-based Pakistani patient. Symptoms resolved with vitamin D therapy, highlighting risks in specific populations.
Area of Science:
- Dermatology
- Endocrinology
- Nutritional Science
Background:
- Chronic actinic dermatitis necessitates strict sunlight avoidance for management.
- Certain dietary components, like phytates in chappattis, can impede calcium absorption.
- Individual risk factors such as skin type and dietary habits play a role in developing deficiencies.
Observation:
- A Pakistani patient in the UK developed incipient osteomalacia.
- The condition arose secondary to rigorous sun avoidance for photosensitive dermatitis.
- Risk factors included fair skin type and a diet rich in phytates.
Findings:
- The patient presented with proximal muscle weakness and bony tenderness.
- These symptoms were indicative of osteomalacia, a bone-softening disease.
- Biochemical and clinical improvements were observed following vitamin D replacement therapy.
Implications:
- This case underscores the potential for vitamin D deficiency in individuals practicing strict sun avoidance.
- Dietary factors can exacerbate the risk of osteomalacia in susceptible populations.
- Effective management requires balancing dermatological treatment with nutritional and metabolic health considerations.
Related Concept Videos
Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Role of Skin in Vitamin D Synthesis
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

