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Related Experiment Videos

Pulmonary tuberculosis and serum IgE.

T Ohrui1, K Zayasu, E Sato

  • 1Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan.

Clinical and Experimental Immunology
|September 30, 2000
PubMed
Summary

Tuberculosis infection significantly lowers IgE levels, a marker of allergic responses. Successful treatment of tuberculosis enhances Th1 immune responses, potentially reducing allergic disorders.

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Allergy Research

Background:

  • Recent studies suggest infections may suppress allergic responses (atopy) by reducing immunoglobulin E (IgE) levels.
  • The role of Mycobacterium tuberculosis infection in modulating Th1/Th2 immune responses and its impact on atopy requires further investigation.

Purpose of the Study:

  • To determine if Mycobacterium tuberculosis infection and its treatment down-regulate serum total IgE levels.
  • To investigate if this down-regulation is linked to an enhanced Th1 response, using tuberculin skin tests as a marker.

Main Methods:

  • Prospective study involving 20 pulmonary tuberculosis (TB) patients, 19 asthma patients, and 10 healthy controls.
  • Serum total IgE levels and delayed-type hypersensitivity (DTH) response to tuberculin were measured before and after 6 months of TB treatment.

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  • Comparisons were made between TB patients, asthma patients, and healthy controls.

    • Main Results:

    • TB patients initially had significantly higher serum IgE levels than healthy controls (282 vs. 126 U/ml).
    • Following successful TB treatment, serum IgE levels significantly decreased (282 to 151 U/ml), and tuberculin skin test responses significantly increased (23.6 to 29.6 mm).
    • No significant changes in IgE or tuberculin responses were observed in healthy controls or asthma patients.

    Conclusions:

    • Immune responses to Mycobacterium tuberculosis infection effectively down-regulate Th2-mediated immune responses, indicated by decreased IgE levels.
    • The enhancement of Th1 responses during TB treatment may contribute to the observed reduction in allergic responses.
    • These findings suggest a potential link between tuberculosis and a decreased prevalence of allergic disorders.