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Inflammation and microalbuminuria in nondiabetic and type 2 diabetic subjects: The Insulin Resistance Atherosclerosis

A Festa1, R D'Agostino, G Howard

  • 1Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, Texas 78228-3900, USA.

Kidney International
|September 30, 2000
PubMed
Abstract

Insights

Microalbuminuria is linked to chronic inflammation, with elevated C-reactive protein (CRP) and fibrinogen levels found in individuals with higher urinary albumin excretion. This suggests inflammation may mediate the link between microalbuminuria and cardiovascular disease.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Inflammation Research

Background:

  • Microalbuminuria is a known cardiovascular disease risk factor, but its underlying mechanisms remain unclear.
  • C-reactive protein (CRP) is a marker of inflammation associated with atherosclerosis.

Purpose of the Study:

  • To investigate the association between microalbuminuria and markers of chronic inflammation, specifically CRP and fibrinogen.
  • To explore these relationships within the Insulin Resistance Atherosclerosis Study (IRAS) population.

Main Methods:

  • Assessed urinary albumin excretion using the albumin-to-creatinine ratio (ACR) in morning urine samples.
  • Measured levels of CRP and fibrinogen in 1481 subjects from the IRAS study, excluding those with macroalbuminuria.

Main Results:

  • Both CRP and fibrinogen showed a significant association with urinary ACR, even after adjusting for confounding factors.
  • Microalbuminuric subjects had significantly higher mean levels of CRP and fibrinogen compared to normoalbuminuric subjects.
  • Fibrinogen, but not CRP, was independently associated with microalbuminuria in a logistic regression model, alongside hypertension, gender, waist circumference, and glucose levels.

Conclusions:

  • CRP and fibrinogen are associated with urinary albumin excretion in individuals with microalbuminuria, including those with and without type 2 diabetes.
  • Chronic inflammation is identified as a potential mediator linking microalbuminuria to macrovascular complications.

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