Related Experiment Video
Updated: Aug 19, 2026

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
Treating obesity. Lost cause or new opportunity?
1Obesity Research Centre, Columbia University, New York, NY, USA. dr_plourde@hotmail.com
Objective:
To review therapies for treating obese patients.
Quality Of Evidence:
Advice in this paper is based mainly on the results of randomized controlled trials. Some data from smaller, more physiologic studies are included. When appropriate, advice is based on consensus.
Main Message:
Recent medical evidence indicates that a modest weight loss (5% to 10%) can alleviate symptoms of obesity-related comorbidity. Treatment of obesity should be comprehensive and integrated into a multi-component approach and should involve both patients and their families. The main challenge of obesity is maintaining a reduced weight.
Conclusion:
A multi-component approach to treating obesity can help make treatment less frustrating and more rewarding for patients and physicians.
Related Concept Videos
Obesity
Drug Dosing: Obese Patients
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Atherosclerosis III: Management
Binge Eating Disorders

