Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Status epilepticus. Current concepts and management.

E Starreveld1, A A Starreveld

  • 1Adult Convulsive Disorder Clinic, Glenrose Rehabilitation Hospital. adaleist@compusmart.ab.ca

Canadian Family Physician Medecin De Famille Canadien
|October 3, 2000
PubMed
Summary

Generalized convulsive status epilepticus (GCSE) is a medical emergency requiring prompt treatment. Initial management with intravenous lorazepam and phenytoin is most effective for this condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of carcinoembryonic antigen in follow-up of patients with ovarian cancer.

Canadian Medical Association journal·2010
Same author

CT-targeted irradiation of the breast and internal mammary lymph nodes using a 5-field technique.

International journal of radiation oncology, biology, physics·2000
Same author

The Canadian National Breast Screening Study: a clinician's perspective.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·1992
Same author

Double-blind cross-over placebo controlled study of flunarizine in patients with therapy resistant epilepsy.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·1989
Same author

Toxicity of abdominopelvic radiation in advanced ovarian carcinoma patients after cisplatin/cyclophosphamide therapy and second-look laparotomy.

Obstetrics and gynecology·1988
Same author

Cerebral metastases from epithelial ovarian carcinoma.

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes·1987

Area of Science:

  • Neurology
  • Emergency Medicine

Background:

  • Generalized convulsive status epilepticus (GCSE) presents significant morbidity and mortality.
  • Prompt and effective management is crucial for patient outcomes.

Purpose of the Study:

  • To provide primary care physicians with current information on GCSE.
  • Emphasis on definition, pathophysiology, treatment, and prognosis of GCSE.

Main Methods:

  • Literature review of MEDLINE database (1994-1999) using "status epilepticus" and "treatment" keywords.
  • Selection of 30 English-language articles focusing on clinical aspects, treatment, and animal research.
  • Inclusion of key documents, textbooks, and symposium information.

Main Results:

  • GCSE definition: seizures >5 minutes or recurrent seizures without recovery.
  • Initial treatment of choice: intravenous lorazepam and phenytoin.
  • Other effective medications include diazepam, midazolam, and propofol.
  • Prognosis depends on cause, treatment delay, and comorbidity.
  • GCSE >30 minutes requires intensive care and EEG monitoring.

Conclusions:

  • Intravenous lorazepam and phenytoin are the most effective initial treatments for GCSE.
  • Timely antiepileptic drug administration can prevent GCSE in some epilepsy patients.
  • Nonepileptic status is a key differential diagnosis.

Related Experiment Videos