[The significance of iron in infant development and nutrition. I. Metabolism of iron]
Related Experiment Video
Updated: Aug 15, 2026

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))
Published on: May 4, 2020
K Wasowska-Królikowska1, W J Baranowski
1Klinika Gastroenterologii i Alergologii Dzieciecej Akademii Medycznej w Lodzi.
Insights
Iron is crucial for child development, with daily requirements varying by age and sex. Infant iron deficiency can stem from blood loss and inadequate intake, impacting growth.
Area of Science:
- Pediatric Nutrition
- Hematology
- Developmental Biology
Context:
- Iron homeostasis is vital for child development.
- Infant iron needs are influenced by growth and physiological losses.
- Blood volume and iron content play a role in iron regulation.
Purpose:
- To describe the role of iron in the child organism.
- To analyze iron homeostasis regulation by blood.
- To calculate average body iron content and daily iron requirements for children aged 0-2 years.
Summary:
- Calculated average daily iron requirements for infants (0-2 years) range from 0.42 to 0.92 mg.
- Physiological iron loss can account for up to 50% of daily requirements in the first two years.
- Infant iron deficiency causes include blood loss, poor diet, and high growth demands.
- Iron needs for development are independent of birth weight, but premature/low birth weight infants require 25-50% more iron after doubling birth weight.
Impact:
- Provides essential data for pediatric iron intake recommendations.
- Highlights the significance of monitoring iron status in infants, especially those at risk.
- Informs strategies for preventing and managing infant iron deficiency.
Abstract:
The role of iron in the child organism, as well as the blood's role in regulating the iron homeostasis is described on the basis of relevant literature. From developmental data on Warsaw children and from relevant literature, the child average body iron content and the child average daily iron requirement, which is at age 0-0.5, 0.5-1 and 1-2 years 0.51, 0.92 and 0.76 mg for boys and for girls 0.42, 0.86 and 0.74 mg respectively, are calculated. It is noted that the daily physiological iron loss during the first two years of life can be as much as 50% of the daily iron requirement. Among the causes of infant iron deficiency are the greater blood losses during the peri- and postnatal periods, decreased dietary iron, as well as increased need for iron related to significant body growth. The loss of one ml of blood in children results in the loss of from 0.33 to 0.66 mg of iron. On the basis of the changes in body iron content of infants having various birth weights, it is shown that the quantity of iron needed for proper development is independent of the birth weight. The quantity of iron required by premature infants and children with low birth weight is 25-50% greater, after the infant doubles its birth weight, than that needed by full-term and normal birth weight infants.
Related Concept Videos
The Early Endosome: Endocytosis of Transferrin
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Minerals
Sulfur Assimilation
Microbes and Other Elemental Cycles
Development of Human Microbiota

