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Meningioma with granulofilamentous inclusions

H Horiguchi1, T Hirose, T Sano

  • 1Department of Neurological Surgery, University of Tokushima, School of Medicine, Japan. hide@basic.med.tokushima-u.ac.jp

Ultrastructural Pathology
|October 3, 2000
PubMed

Insights

This study details an intracranial meningioma case with unique granulofilamentous inclusions. Advanced microscopy suggests these inclusions may be metabolic byproducts of vimentin filaments.

Area of Science:

  • Neuropathology
  • Oncology

Background:

  • Intracranial meningiomas are common primary tumors of the central nervous system.
  • Petroclival meningiomas can cause significant neurological deficits, such as trigeminal neuralgia, due to nerve compression.

Observation:

  • A case of a 50-year-old male with trigeminal neuralgia caused by a petroclival meningioma is presented.
  • Microscopic examination revealed meningioma cells with eccentric nuclei and intracytoplasmic hyaline inclusions, arranged in sheets and whorls.
  • The inclusions were periodic acid-Schiff negative, and no anaplasia was observed.

Findings:

  • Immunohistochemistry showed epithelial membrane antigen on the cell membrane and vimentin in the cytoplasm adjacent to inclusions.
  • Confocal laser microscopy revealed vimentin immunoreactivity within some inclusions.
  • Electron microscopy identified inclusions composed of fine granules attached by intermediate filaments, suggesting a link to vimentin.

Implications:

  • The findings support meningioma as the diagnosis, characterized by specific granulofilamentous inclusions.
  • Advanced microscopy techniques suggest these inclusions represent metabolic products of vimentin filaments.
  • This case expands the understanding of meningioma ultrastructural variations and potential cellular processes.

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