Related Experiment Videos
Meningioma with granulofilamentous inclusions
H Horiguchi1, T Hirose, T Sano
1Department of Neurological Surgery, University of Tokushima, School of Medicine, Japan. hide@basic.med.tokushima-u.ac.jp
Ultrastructural Pathology
|October 3, 2000
Summary
This study details an intracranial meningioma case with unique granulofilamentous inclusions. Advanced microscopy suggests these inclusions may be metabolic byproducts of vimentin filaments.
Area of Science:
- Neuropathology
- Oncology
Background:
- Intracranial meningiomas are common primary tumors of the central nervous system.
- Petroclival meningiomas can cause significant neurological deficits, such as trigeminal neuralgia, due to nerve compression.
Observation:
- A case of a 50-year-old male with trigeminal neuralgia caused by a petroclival meningioma is presented.
- Microscopic examination revealed meningioma cells with eccentric nuclei and intracytoplasmic hyaline inclusions, arranged in sheets and whorls.
- The inclusions were periodic acid-Schiff negative, and no anaplasia was observed.
Findings:
- Immunohistochemistry showed epithelial membrane antigen on the cell membrane and vimentin in the cytoplasm adjacent to inclusions.
- Confocal laser microscopy revealed vimentin immunoreactivity within some inclusions.
- Electron microscopy identified inclusions composed of fine granules attached by intermediate filaments, suggesting a link to vimentin.
Implications:
- The findings support meningioma as the diagnosis, characterized by specific granulofilamentous inclusions.
- Advanced microscopy techniques suggest these inclusions represent metabolic products of vimentin filaments.
- This case expands the understanding of meningioma ultrastructural variations and potential cellular processes.