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[Ross operation in aortic valve diseases].

¹Universitätsklinikum Lübeck Klinik für Herzchirurgie.

Zeitschrift Fur Kardiologie

|October 3, 2000

Summary

The pulmonary autograft demonstrates superior performance compared to other heart valve replacements, offering excellent function without the need for anticoagulation. Further research is needed to optimize long-term outcomes, particularly for the neopulmonary valve.

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Area of Science:

Cardiovascular Surgery
Biomedical Engineering
Regenerative Medicine

Background:

Standard mechanical and bioprosthetic heart valves have inherent limitations impacting patient outcomes.
The pulmonary autograft presents a promising alternative with theoretical advantages requiring clinical validation.

Purpose of the Study:

To evaluate the long-term performance and clinical effectiveness of the pulmonary autograft as a heart valve replacement.
To compare the autograft's outcomes against existing mechanical and bioprosthetic valves.

Main Methods:

Analysis of an international registry data (2523 patients) and 10-year single-center experience (157 patients).
Inclusion of diverse patient demographics (ages 1-79) and concomitant surgical procedures.
Assessment of operative mortality, functional outcomes, and revision rates.

Main Results:

Low operative mortality (0.6-2.5%) and no requirement for anticoagulation.
Excellent autograft function with minimal aortic insufficiency (<5%) and no exercise-induced pressure gradients.
Low rates of autograft failure (1-4%) and homograft revision (1-1.3%).

Conclusions:

Multicenter data confirm the pulmonary autograft's superior performance over mechanical and bioprosthetic valves.
The autograft offers excellent function and durability, making it a highly effective option for heart valve replacement.
Continued scientific investigation is essential to further enhance the long-term function of the neopulmonary valve.

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