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[Hybrid (bioartificial) systems for liver support. History and current developments].

E Morsiani1

  • 1Sezione di Patologia Speciale Chirurgica, Azienda Ospedaliera Arcispedale Sant'Anna, Ferrara.

Annali Italiani Di Chirurgia
|October 3, 2000
PubMed
Summary

Developing effective artificial liver support systems remains a challenge. Bioartificial liver devices, combining artificial components with isolated hepatocytes, show promise for acute liver failure treatment.

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Retinoic acid maintains differentiated cell morphology and functions in long-term cultured porcine hepatocytes: obtaining functional cells for prolonged treatments with bioartificial liver.

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Modulation of pro-apoptotic (Bax) and anti-apoptotic (Bcl-2) gene expression in isolated porcine hepatocytes perfused within a radial-flow bioreactor after low-temperature storing.

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Biologic liver support: optimal cell source and mass.

The International journal of artificial organs·2002

Area of Science:

  • Hepatology and Regenerative Medicine
  • Biomedical Engineering
  • Artificial Organ Development

Context:

  • Acute liver failure (ALF) presents a critical unmet medical need.
  • Liver transplantation is the only definitive treatment but faces organ scarcity.
  • Previous artificial liver support systems have shown limited clinical success.

Purpose:

  • To review the historical development and current state of artificial liver support systems.
  • To highlight the potential of hybrid or bioartificial liver (BAL) devices.
  • To discuss the integration of isolated hepatocytes with artificial components.

Summary:

  • Past attempts at artificial liver support, including hemodialysis and bioreactors, have not significantly improved patient survival.

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  • Liver transplantation remains the gold standard but is limited by organ availability.
  • Hybrid/BAL systems integrate biological components (isolated hepatocytes) with artificial elements (membranes, resins) for enhanced liver function support.

    • Impact:

    • This review underscores the urgent need for effective liver support technologies.
    • Bioartificial liver systems represent a promising avenue to bridge the gap in liver transplantation.
    • Further research into BAL technology could significantly improve outcomes for ALF patients.