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Related Experiment Videos

Putative peripheral neuropathy in suckling piglets.

G Sályi1, R Glávits, T Molnár

  • 1Central Veterinary Institute, Budapest, Hungary.

Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health
|October 3, 2000
PubMed
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A progressive motor disturbance affected young piglets, causing paralysis and limb lesions. Investigations ruled out common toxins and nutritional deficiencies, leaving the cause of this piglet neurological disease unclear.

Area of Science:

  • Veterinary Neurology
  • Swine Production Medicine
  • Animal Pathology

Background:

  • A significant percentage of piglets in a large swine herd exhibited progressive motor disturbances.
  • Clinical signs included movement difficulties and abnormal limb posture starting at 3-5 days of age.
  • Secondary infections led to inflammatory and necrotic lesions on paralyzed limbs post-weaning.

Purpose of the Study:

  • To investigate the etiology of a progressive motor disturbance affecting piglets.
  • To identify potential causes including toxic, nutritional, and infectious agents.
  • To differentiate this condition from other neurological or musculoskeletal disorders in swine.

Main Methods:

  • Clinical examination of affected piglets and littermates.

Related Experiment Videos

  • Histopathological evaluation of peripheral nerves (tibial and common fibular nerves).
  • Toxicological screening for heavy metals (lead, copper, cadmium).
  • Assessment of vitamin B2 supplementation and dietary factors, including milk whey exclusion.

    • Main Results:

    • Peripheral nerve damage (degeneration, demyelination, necrosis) was observed in affected piglets.
    • Central nervous system, bones, muscles, tendons, and joints showed no primary lesions.
    • Toxicological tests for lead, copper, and cadmium were negative.
    • Vitamin B2 supplementation was ineffective.
    • The disease did not occur in piglets from sows on a farm with an identical diet except for the absence of milk whey.
    • Triaryl phosphate (TAP) poisoning was investigated and ruled out.

    Conclusions:

    • The motor disturbance is characterized by peripheral nerve pathology.
    • Common heavy metal toxicities and vitamin B2 deficiency were excluded as causes.
    • Dietary factors, specifically the exclusion of milk whey on a control farm, suggest a potential link to feed composition.
    • Despite extensive investigation, the specific etiology of the piglet motor disturbance remains undetermined.