Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The IGF system: summary and recent data].

R Winkler1, F Pasleau, N Boussif

  • 1Département de Pathologie, Université de Liège.

Revue Medicale De Liege
|October 3, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coherent control of rare earth 4f shell wavefunctions in the quantum spin liquid Tb<sub>2</sub>Ti<sub>2</sub>O<sub>7</sub>.

Nature communications·2024
Same author

Origin of Pinning Disorder in Magnetic-Field-Induced Wigner Solids.

Physical review letters·2024
Same author

Fractional Quantum Hall State at Filling Factor ν=1/4 in Ultra-High-Quality GaAs Two-Dimensional Hole Systems.

Physical review letters·2024
Same author

Highly Anisotropic Even-Denominator Fractional Quantum Hall State in an Orbitally Coupled Half-Filled Landau Level.

Physical review letters·2023
Same author

Valley-Tunable Even-Denominator Fractional Quantum Hall State in the Lowest Landau Level of an Anisotropic System.

Physical review letters·2023
Same author

Use of Compton suppression gamma ray spectrometry to determine <sup>239</sup>Pu.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2023

The Insulin-like Growth Factor (IGF) system is crucial for cell differentiation and offers protection to the nervous and cardiovascular systems. Cancer cells exploit IGFs for survival, but the system also presents potential therapeutic targets for cancer and other diseases.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Cell Biology

Context:

  • The Insulin-like Growth Factor (IGF) system, previously known for trophic and mitogenic roles, is now recognized for its critical functions in cellular differentiation.
  • IGFs act as potent protective agents for the nervous and cardiovascular systems under normal physiological conditions.

Purpose:

  • To summarize current knowledge of the IGF system and present recent data on its multifaceted roles.
  • To highlight the dual nature of IGFs, beneficial in physiological states but subverted in cancer.
  • To discuss the therapeutic potential and challenges of targeting the IGF system.

Summary:

  • IGFs are essential for cell differentiation and provide neuroprotection and cardioprotection.
  • Cancer cells hijack IGF properties to enhance survival and resist treatments.

Related Experiment Videos

  • IGFs show promise in treating severe neurological, renal, and muscle diseases, despite past limitations in diabetes treatment.

    • Impact:

    • Understanding the IGF system's roles can lead to novel therapeutic strategies for degenerative diseases.
    • Targeting the IGF system presents a potential avenue for innovative cancer therapies.
    • This research provides a comprehensive overview of the evolving understanding and applications of the IGF system.