Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute thymic involution in fetuses and neonates with chorioamnionitis.

P Toti1, C De Felice, M Stumpo

  • 1Institute of Pathology, University of Siena, Italy.

Human Pathology
|October 3, 2000
PubMed
Summary

Chorioamnionitis, an infection during pregnancy, significantly alters fetal thymus development, leading to reduced organ size and thymocyte depletion, even without sepsis. This impacts preterm birth outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of psa levels and pathological stadiation before radiation therapy in predicting mp-MRI results in patients with prostate cancer recurrence after radical prostatectomy.

Actas urologicas espanolas·2023
Same author

Effectiveness of etanercept biosimilar SB4 in maintaining low disease activity in patients with psoriatic arthritis switched from etanercept originator: an open-label one year study.

The Journal of dermatological treatment·2019
Same author

Fetal pain debate may weaken the fight for newborns' analgesia.

The journal of pain·2019
Same author

Different concentration of human cord blood HMGB1 according to delivery and labour: A pilot study.

Cytokine·2018
Same author

Predictive Role of F<sub>2</sub>-Isoprostanes as Biomarkers for Brain Damage after Neonatal Surgery.

Disease markers·2017
Same author

Pain perception in NICU: a pilot questionnaire.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2017

Area of Science:

  • Pathology
  • Neonatalogy
  • Immunology

Background:

  • Chorioamnionitis is a primary cause of preterm birth and fetal death.
  • Subclinical chorioamnionitis has been linked to reduced thymus size in preterm infants.
  • Morphologic changes in the fetal thymus due to chorioamnionitis are not well-described.

Purpose of the Study:

  • To describe the morphologic modifications of the thymus gland in fetuses and neonates with chorioamnionitis.
  • To investigate the impact of chorioamnionitis, with or without sepsis, on thymic pathology.

Main Methods:

  • Histologic examination of thymuses from fetuses and neonates with confirmed chorioamnionitis.
  • Analysis of thymic organ volume, corticomedullary ratio, thymocyte counts, and interstitial tissue changes.

Related Experiment Videos

  • Statistical analysis (ANOVA) to assess the significance of observed changes.

    • Main Results:

    • Decreased thymic organ volume (P < .0024).
    • Reduced corticomedullary ratio (P < 10(-6)).
    • Increased thymic organ complexity due to altered parenchyma-interstitial tissue relationship (P = .03).
    • Severe reduction in thymocytes and degenerative changes like monocyte/macrophage infiltration of Hassall's bodies.

    Conclusions:

    • Chorioamnionitis, with or without sepsis, is associated with significant thymic morphologic modifications.
    • These thymic changes are part of the fetal systemic inflammatory response to chorioamnionitis.
    • The findings highlight a critical aspect of fetal response to intrauterine infection.