Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

83.5K
Overview
83.5K
T Cell Types and Functions01:24

T Cell Types and Functions

2.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.2K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.8K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.8K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

6.5K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.5K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

2.9K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
2.9K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

9.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An immunosuppressive factor interacts with membrane glycolipid asialo-GM1 structure.

Immunobiology·1987
Same author

Correlation between immunosuppressive activity and translation regulatory activity.

Immunology letters·1985
Same author

The effect of febrile temperatures on biologic actions of interferons: abrogation of suppression of delayed-type hypersensitivity and antibody production.

Journal of immunology (Baltimore, Md. : 1950)·1984
Same author

Antigen-specific T contrasuppressor factor in cell-mediated immunity: interactions leading to eradication of the tolerant state.

Journal of immunology (Baltimore, Md. : 1950)·1984
Same author

Production of antigen-specific contrasuppressor cells and factor, and their use in augmentation of cell-mediated immunity.

Journal of immunology (Baltimore, Md. : 1950)·1984
Same author

Thymus-derived lymphocytes and their interactions with macrophages are required for the production of osteoclast-activating factor in the mouse.

Proceedings of the National Academy of Sciences of the United States of America·1984
Same journal

The nude mouse vs. the hypothesis of immunological surveillance.

Transplantation reviews·1976
Same journal

Complement and cell membranes.

Transplantation reviews·1976
Same journal

Allotypes of complement components in man.

Transplantation reviews·1976
Same journal

The S region of the mouse major histocompatibility complex (H-2): genetic variation and functional role in complement system.

Transplantation reviews·1976
Same journal

Role of complement in the induction of immunological responses.

Transplantation reviews·1976
Same journal

The HLA system and inherited deficiencies of the complement system.

Transplantation reviews·1976
See all related articles

Related Experiment Video

Updated: Jan 19, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

8.6K

A disquisition on suppressor T cells.

R K Gershon

    Transplantation Reviews
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Suppressor T cell activity is complex, influenced by target cell feedback and antigen triggers. Immune responses require countermanding signals, and memory T cells exhibit distinct sensitivities.

    More Related Videos

    Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
    07:17

    Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

    Published on: June 22, 2016

    10.3K
    Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
    15:33

    Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

    Published on: August 13, 2013

    16.4K

    Related Experiment Videos

    Last Updated: Jan 19, 2026

    Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
    08:41

    Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

    Published on: June 7, 2017

    8.6K
    Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
    07:17

    Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

    Published on: June 22, 2016

    10.3K
    Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
    15:33

    Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

    Published on: August 13, 2013

    16.4K

    Area of Science:

    • Immunology
    • Cellular Biology

    Background:

    • Suppressor T cells play a critical role in immune regulation.
    • Understanding the precise mechanisms governing T cell suppression is essential for controlling immune responses.

    Purpose of the Study:

    • To elucidate the complex factors regulating suppressor T cell activity.
    • To differentiate the roles of feedback signals, antigen triggering, and cell type in immune suppression.

    Main Methods:

    • Analysis of feedback mechanisms in suppressor T cell function.
    • Investigation of antigen-specific T cell triggering and immune response generation.
    • Comparative study of B cell tolerance induction across different developmental stages.
    • Examination of suppressor cell generation through cellular interactions.

    Main Results:

    • Suppressor T cell activity is not solely due to excessive help but is critically modulated by target cell feedback signals.
    • Antigen triggering of T cells invariably leads to suppression, necessitating countermanding signals for immune responses.
    • Memory T cells display altered sensitivity to feedback and suppression compared to normal T cells.
    • Mature B cells resist antigen-induced tolerance, unlike immature or thymus-independent B cells.
    • Distinct mechanisms underlie suppression induced by exogenous antigens versus differentiation products.
    • The generation of suppressor cells involves intricate cell subpopulation interactions, currently hindering precise cell-specific attribution.

    Conclusions:

    • Suppressor T cell function is a multifaceted process influenced by crucial feedback loops and cellular interactions.
    • Further research is imperative to fully comprehend the significance and operational mechanisms of suppressor T cells in immunity.