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Updated: Oct 11, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Trisomy 14 with thrombocytosis and monocytosis
H Kaya1, S Nakamura, K Okafuji
1Department of Internal Medicine, Fukui-ken Saiseikai Hospital, Fukui, Japan.
Abstract:
It has been reported that trisomy 14 is associated with myeloid malignancies, but a case with increased platelet count has also been reported. However, the clinical significance of trisomy 14 is still uncertain. We report a patient with trisomy 14 with thrombocytosis and a gradual increase in monocytosis. He was treated with hydroxyurea, cytarabine and aclarubicin in low doses and his quality of life was maintained for a period of about 1 year from blastic crisis. Hydroxyurea, cytarabine or aclarubicin in low doses may be the treatment of choice for trisomy 14 patients with respect to the patients' quality of life.
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