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Changes in plasma adenosine concentrations during normal pregnancy.

Y Yoneyama1, S Suzuki, R Sawa

  • 1Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan. yoshi-1@nms.ac.jp

Gynecologic and Obstetric Investigation
|October 3, 2000
PubMed
Summary

Plasma adenosine levels increase significantly in the third trimester of pregnancy. This rise in adenosine concentration is linked to activated platelets, suggesting their role in pregnancy-related adenosine changes.

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Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Physiology
  • Hematology

Background:

  • Adenosine (ADO) plays a crucial role in physiological processes.
  • Changes in plasma adenosine concentration during pregnancy are not well understood.
  • Platelets and red blood cells (RBCs) are potential sources of plasma adenosine.

Purpose of the Study:

  • To measure plasma adenosine concentration throughout normal pregnancy.
  • To investigate the contribution of platelets and RBCs to plasma adenosine changes during pregnancy.

Main Methods:

  • Plasma ADO levels were measured in 11 normal pregnant women across three trimesters.
  • Platelet counts, RBC counts, hematocrit, and hemoglobin were monitored.
  • Correlation analysis was performed between plasma ADO and hematological parameters.

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Main Results:

  • Mean plasma ADO was significantly higher in the third trimester compared to the first and second trimesters (p < 0.05).
  • Platelet and RBC counts, hematocrit, and hemoglobin showed a slight decrease during pregnancy.
  • Plasma ADO elevation in the third trimester showed an inverse correlation with platelet count (r = -0.43, p < 0.05).

Conclusions:

  • Plasma adenosine concentration increases significantly in the third trimester of normal pregnancy.
  • Enhanced adenosine release from activated platelets is a likely contributor to elevated plasma ADO during late pregnancy.
  • This finding highlights the potential role of platelet activity in modulating adenosine levels during gestation.