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Nausea and vomiting in pregnancy: an association between symptoms and maternal prostaglandin E2
R Gadsby1, A Barnie-Adshead, D Grammatoppoulos
1GP Nuneaton and Warwick University, Coventry, UK. R.Gadsby@warwick.ac.uk
This study investigated the aetiology of nausea and vomiting in pregnancy (NVP) in primary care using a new methodology. Eighteen women in early pregnancy had 2 blood samples taken in one 24-hour time period, one when they were symptomatic, and another when they were symptom-free. Maternal serum levels of the candidate agents PGE2, IL-1beta, and TNFalpha were measured. The study shows a positive relationship between NVP and maternal serum PGE2 levels in early pregnancy.
This study investigated the aetiology of nausea and vomiting in pregnancy (NVP) in primary care using a new methodology. Eighteen women in early pregnancy had 2 blood samples taken in one 24-hour time period, one when they were symptomatic, and another when they were symptom-free. Maternal serum levels of the candidate agents PGE2, IL-1beta, and TNFalpha were measured. The study shows a positive relationship between NVP and maternal serum PGE2 levels in early pregnancy.