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Updated: Aug 4, 2026

Expired CO2 Measurement in Intubated or Spontaneously Breathing Patients from the Emergency Department
Published on: January 29, 2011
The effect of carbonated beverages on colorimetric end-tidal CO(2) determination
1Beth Israel Medical Center, New York, University Hospital and Manhattan Campus of The Albert Einstein College of Medicine, New York, NY.
Abstract:
Esophageal intubation is a significant complication of attempted airway control. Colorimetric end-tidal CO(2) monitors are highly sensitive and specific for detecting the presence of CO(2). There are reports of false-positive end-tidal CO(2) readings from esophageal intubations in patients who had ingested carbonated beverages. OBJECTIVE: To determine whether carbonated gastric contents can affect colorimetric end-tidal CO(2) readings. METHODS: End-tidal CO(2) was measured in sacrificed piglets at measured time intervals after instillation of 5-, 10-, 15-, and 20-mL aliquots of Diet Coke were placed into the stomach via a 28-French orogastric tube followed by esophageal intubation. The stomach was completely evacuated prior to each instillation and rechecked for baseline CO(2). RESULTS: Compiled data from three piglets (20-30 kg). Piglets were not ventilated or moved and determinations were measured at 20 degrees while supine. All data collected within 2 hours postmortem (table 24-1). CONCLUSIONS: The colorimetric end-tidal CO(2) turned "yellow" and did not change to blue with extended insufflations. The CO(2) of a small quantity of carbonated beverage in the stomach could be "blown off" by multiple insufflations. We conclude that esophageal intubation in the setting of recent ingestion of a carbonated beverage may result in a false-positive end-tidal CO(2) determination.
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