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Selenium levels in dilated cardiomyopathy.

J Vijaya1, G Subramanyam, V Sukhaveni

  • 1Department of Cardiology, SV Medical College, Tirupati.

Journal of the Indian Medical Association
|October 4, 2000
PubMed
Summary
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This study found that low selenium levels, combined with factors like high cholesterol and obesity, are linked to dilated cardiomyopathy. These findings highlight selenium

Area of Science:

  • Cardiology
  • Nutritional Science
  • Biochemistry

Background:

  • Dilated cardiomyopathy (DCM) is a significant cause of heart failure.
  • Coronary risk factors are implicated in cardiovascular diseases.
  • The role of trace elements like selenium in DCM requires further investigation.

Purpose of the Study:

  • To investigate serum selenium levels in patients with dilated cardiomyopathy.
  • To examine the association between selenium levels and traditional coronary risk factors in DCM patients.
  • To compare selenium and lipid profiles between DCM patients and healthy controls.

Main Methods:

  • A case-control study involving 37 DCM patients and 20 healthy controls.
  • Serum analysis for selenium, total cholesterol, HDL cholesterol, triglycerides, and glucose.

Related Experiment Videos

  • Assessment of various coronary risk factors including smoking, alcohol intake, family history, psychosocial tension, obesity, hypercholesterolemia, hypertriglyceridemia, and hyperglycemia.

    • Main Results:

    • DCM patients exhibited higher prevalence of psychosocial tension (73%), hypertriglyceridemia (81%), and hypercholesterolemia (38%) compared to controls.
    • Significantly lower serum selenium (< 4.5 µg/dL) and HDL cholesterol levels were observed in DCM patients.
    • Elevated levels of total cholesterol, triglycerides, LDL cholesterol, VLDL cholesterol, and glucose were found in DCM cases.

    Conclusions:

    • Low serum selenium levels are associated with dilated cardiomyopathy.
    • Selenium deficiency, alongside other cardiovascular risk factors, may contribute to the pathogenesis of DCM.
    • Further research is warranted to explore selenium supplementation as a potential therapeutic strategy for DCM.