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Basic fibroblast growth factor may improve devascularized sternal healing.

A Iwakura1, Y Tabata, K Nishimura

  • 1Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine and Institute for Frontier Medical Sciences and College of Medical Technology, Kyoto University, Japan.

The Annals of Thoracic Surgery
|October 4, 2000
PubMed
Summary
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Basic fibroblast growth factor sheets significantly accelerated sternal bone regeneration and remodeling in rats. This topical application improved healing and blood flow in devascularized sternums.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Orthopedic Surgery

Background:

  • Previous studies demonstrated basic fibroblast growth factor (bFGF) enhanced bone regeneration in devascularized sternums using a gelatin sheet.
  • The current study investigates if topical bFGF accelerates normal sternal regeneration and bone remodeling.

Purpose of the Study:

  • To evaluate the efficacy of topical basic fibroblast growth factor (bFGF) in accelerating sternal bone regeneration and remodeling.
  • To assess the impact of bFGF on blood flow, angiogenesis, and bone healing in a rat sternotomy model.

Main Methods:

  • Thirty Wistar rats underwent median sternotomy and were divided into three groups.
  • Group A: Bilateral internal thoracic arteries removed, bFGF sheet applied to the sternum.

Related Experiment Videos

  • Group B: Bilateral internal thoracic arteries removed (control). Group C: Intact bilateral internal thoracic arteries (control).

    • Main Results:

    • Group A showed significantly increased peristernal blood flow and marked angiogenesis around the sternum after four weeks.
    • Histological analysis revealed near-complete sternal healing exclusively in Group A.
    • Group A exhibited the highest bone mineral content and an elevated osteoclast index, indicating enhanced bone remodeling.

    Conclusions:

    • Topical basic fibroblast growth factor (bFGF) effectively offsets sternal ischemia and accelerates bone regeneration.
    • bFGF promotes sternal healing not only through callus formation but also via enhanced callus resorption.
    • The bFGF-impregnated gelatin sheet is a promising therapeutic approach for improving sternal bone repair and remodeling.