Related Experiment Video
Updated: Oct 11, 2026
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
Randomized trial of regional plus systemic fluorinated pyrimidine compared with systemic fluorinated pyrimidine in
T G Allen-Mersh1, C Glover, C Fordy
1Department of Surgical Oncology, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, UK. t.allenmersh@ic.ac.uk
Aim:
We report a prospective randomized study comparing survival, response and toxicity in colorectal liver metastasis (CLM) patients treated by either hepatic arterial floxuridine (HAI) plus continuous systemic fluorouracil/folinic acid or systemic fluorouracil/folinic acid.
Methods:
Eighty-four CLM patients received either HAI plus systemic fluorouracil/folinic acid or systemic fluorouracil/ folinic acid.
Results:
Significantly more HAI plus systemic, compared with systemic only, patients developed WHO grade 3 or 4 diarrhoea (P=0.004), but significant quality of life differences were not detected. Liver metastasis partial response at 4 months after randomization was significantly greater (P=0.003) in HAI plus systemic (13/29, 45%) compared with systemic only (7/30, 23%) patients. There was no significant difference between groups in the proportion of patients who died from extrahepatic disease progression, or in survival.
Conclusion:
Combining regional with systemic fluorinated pyrimidines did not improve survival compared with systemic fluorinated pyrimidine.
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