Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rupture of multiple parallel molecular bonds under dynamic loading.

U Seifert1

  • 1Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Am Mühlenberg 2, 14476 Golm, Germany.

Physical Review Letters
|October 4, 2000
PubMed
Summary

This study explores how multiple biological bonds break under force. We found that the rupture force can scale linearly, with a square root, or logarithmically with the number of bonds.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DiscovEpi: automated whole proteome MHC-I-epitope prediction and visualization.

BMC bioinformatics·2024
Same author

Do pneumatic tube transport systems transmit potential pathogens? A hygienic risk assessment in a university hospital.

The Journal of hospital infection·2019
Same author

Nonequilibrium depletion interactions in active microrheology.

Soft matter·2017
Same author

Driven Brownian particle as a paradigm for a nonequilibrium heat bath: Effective temperature and cyclic work extraction.

Physical review. E·2017
Same author

[Spectrum of pathogens in postoperative complications of visceral surgery : The problem of multidrug resistance].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2017
Same author

Discontinuous thinning in active microrheology of soft complex matter.

Physical review. E·2017

Area of Science:

  • Biophysics
  • Molecular Biology
  • Biochemistry

Background:

  • Biological adhesion relies on specific receptor-ligand interactions.
  • Understanding bond rupture is crucial for cellular processes.

Purpose of the Study:

  • To theoretically investigate the rupture dynamics of multiple parallel biological bonds.
  • To analyze the effect of thermal activation and dynamic loading on bond rupture.
  • To identify different scaling regimes for rupture time and force.

Main Methods:

  • Utilizing rate equations to model the rupture process.
  • Applying dynamic loading with thermal activation.
  • Analyzing a simple, generic type of cooperativity between bonds.

Main Results:

  • Identified distinct scaling regimes for rupture time and force.
  • Predicted that rupture force dependence on the number of bonds can be linear, square root, or logarithmic.
  • Demonstrated the influence of cooperativity on rupture mechanics.

Conclusions:

  • The rupture of multiple parallel bonds exhibits complex scaling behaviors.
  • Theoretical models can predict diverse force-dependent rupture outcomes.
  • Findings offer insights into the mechanics of biological adhesion.

Related Experiment Videos