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Effect of carbon monoxide on maximal treadmill exercise. A study in normal persons
Annals of Internal Medicine
|October 1, 1975
Summary
Breathing carbon monoxide (CO) significantly reduces exercise capacity in healthy individuals. Even moderate CO exposure impairs performance and can lead to cardiac strain, highlighting risks from smoking and pollution.
Area of Science:
- Environmental Health
- Cardiovascular Physiology
- Exercise Science
Background:
- Carbon monoxide (CO) is a common environmental pollutant.
- Exposure to CO can affect oxygen transport in the blood.
Purpose of the Study:
- To investigate the impact of breathing 100 ppm carbon monoxide on maximal exercise performance in healthy adults.
- To assess physiological responses, including carboxyhemoglobin levels and exercise duration, under controlled CO exposure.
Main Methods:
- A double-blind, crossover study design was employed.
- Ten healthy, middle-aged, non-smoking adults participated.
- Subjects underwent maximal treadmill exercise after breathing either 100 ppm CO or purified air for 1 hour.
Main Results:
- Breathing CO significantly increased mean venous carboxyhemoglobin levels (1.67% to 3.95%).
- Mean exercise time until exhaustion significantly decreased after CO exposure (697.7s to 662.7s).
- One subject experienced ischemic S-T segment depression after CO inhalation.
Conclusions:
- Elevated carboxyhemoglobin levels, similar to those from smoking or pollution, impair exercise performance in healthy individuals.
- Carbon monoxide exposure can negatively affect cardiovascular function during exertion.
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