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Related Experiment Videos

Pregnancy-associated plasma protein-E (PAPP-E).

M Farr1, J Strübe, H G Geppert

  • 1Department of Biochemistry I, Faculty of Chemistry and Biochemistry, University of Bielefeld, D-33501, Bielefeld, Germany. mfarr@hdz-nrw.de

Biochimica Et Biophysica Acta
|October 6, 2000
PubMed
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A novel human protein, pregnancy-associated plasma protein-E (PAPP-E), was identified with high homology to PAPP-A. PAPP-E is predominantly expressed in the placenta and may play a role in early tissue differentiation.

Area of Science:

  • Biochemistry
  • Genetics
  • Molecular Biology

Background:

  • Pregnancy-associated plasma protein-A (PAPP-A) is a known diagnostic marker for trisomies, including Down syndrome.
  • Novel proteins with potential diagnostic or functional roles in pregnancy are of significant interest.

Purpose of the Study:

  • To clone and characterize a novel human protein with homology to PAPP-A.
  • To investigate the gene localization, domain structure, and expression pattern of the newly identified protein.

Main Methods:

  • Cloning of a full-length cDNA from human placenta.
  • Bioinformatic analysis of the protein sequence for conserved domains.
  • Gene localization using chromosome mapping.
  • Northern blot analysis for tissue-specific expression.

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Main Results:

  • A novel human protein, termed pregnancy-associated plasma protein-E (PAPP-E), was identified.
  • PAPP-E shares 62% homology with PAPP-A and possesses domains related to complement proteins, selectins, lin-notch, and metalloproteases.
  • The PAPP-E gene was mapped to chromosome 1q23-25.
  • PAPP-E is predominantly expressed in the placenta.

Conclusions:

  • PAPP-E is a newly discovered human protein with structural similarities to PAPP-A.
  • Its domain structure suggests potential roles in complement regulation, cell adhesion, and tissue differentiation.
  • The predominant placental expression indicates a potential role in pregnancy, warranting further investigation.